产品货号：
Z11462
中文名称：
BACE1抗体
英文名称：
Anti-BACE1 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-BACE1 Antibody |
| 指标别名 | Asp 2;ASP2;Aspartyl protease 2;BACE;BACE1;Beta secretase 1;HSPC104;KIAA1149;Memapsin 2 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ELISA,WB,ICC,IHC,IF |
| 基因名称 | BACE1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Anti-BACE antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human BACE.The immunogen is located within the last 50 amino acids of BACE. |
| 计算分子量 | 56kDa |
| 成分 | BACE Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | BACE Antibody is Ion exchange chromatography purified. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease.Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases.APP is first cleaved by beta-secretase,producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99).The C99 fragment serves as substrate for gamma-secretase to generate the 4kDa amyloid-beta peptide,which is deposited in the brains of all suffers of Alzheimer's disease.The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2).BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP. |
| Uniprot ID | P56817 |
| 基因名全称 | Beta-site APP-cleaving enzyme 1 |
| 蛋白名全称 | Beta-site APP-cleaving enzyme 1 |
| 推荐稀释比 | WB:1μg/mL;IHC:2.5μg/mL;ICC:10μg/mL;IF:20μg/mL.Antibody validated:Western Blot in human and mouse samples;Immunohistochemistry,Immunocytochemistry and Immunofluorescence in mouse samples.All other applications and species not yet tested. |
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